Iniciando com SQLAlchemy (Python)

Instalar o pacote do SQLAlchemy pelo repositório PiPy

pip install sqlalchemy

engine = create_engine('sqlite:///mydb.db', poolclass=SingletonThreadPool)

Base.metadata.create_all(engine)

Session = sessionmaker(bind=engine)
session = Session()

class User(Base):

    __tablename__ = 'users'

    id          =   Column(Integer, primary_key=True)
    user        =   Column(String(50), nullable=False)
    password    =   Column(String(50), nullable=False)    

    def __repr__(self):
        return "<User (user='%d')>" % (self.user)

Referências

First steps with SQLAlchemy